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The targeted enrollment, reported on a government database and confirmed by the company, is double the size of other pivotal studies that have started recently or are expected imminently for vaccines developed by Moderna Inc. The late-stage, or phase 3, coronavirus vaccine trials depend on a certain number of subjects being exposed to the virus to see if the vaccinated subjects were protected against Covid symptoms compared with the unvaccinated. William Schaffner, infectious-disease specialist and professor of preventive medicine at Vanderbilt University School of Medicine, said reaching the numbers needed to detect whether the vaccine is working could happen more quickly if more people are enrolled. Shaffner, who serves on a liaison committee to a federal vaccine-advisory panel, and is not involved in designing the trial. The company, based in New Brunswick, N. Its vaccine uses a weakened common cold virus to deliver genetic instructions for human cells to manufacture a protein found on the surface of the new coronavirus.

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